Cosmos caudatus or people called “Ulam Raja” is one of good herb plant with the present of antibacterial activity. The aim of study is to determine the potential of C. caudatus with different solvent extraction such as ethanol, methanol, hexane and distilled water against Streptococcus sp. The antibacterial activity were determine by using agar well diffusion method. The result showed, the largest inhibition zone was 1.11±0.02 mm in C. caudatus extract with ethanol and followed by methanol 0.93±0.12 mm and hexane 0.5±0.00mm. There are no inhibition zone in C. caudatus plant species in distilled water and control treatment. The result showed that, there are present of antibacterial properties in C. caudatus extraction against Streptococcus sp. Further study need to be continue to know other component in C. caudatus that can be used in other research. Besides that, C.caudatus also can be used in other pathogen to analysis the reaction towards.