Oreochromus .sp or also known as Red Tilapia is freshwater fish that always been cultured in world. A one month’s research was conducted in glass tanks with Ninety fish of tilapia (Oreochromus .sp) same size were selected for analysis of the effect of difference salinity on growth quality, survivality and flesh quality in Red Tilapia. Each fish was measured growth quality, survivality and flesh quality in Red Tilapia (Oreochromis sp) in different salinity which is 0 ppt, 15 ppt and 32 ppt. The fish were put directly into the three different salinity of water. Each fish was weight for every week to observe the weight increase, the number of mortality and diameter of flesh also recorded. Result for survivality shows that most high survivality rate is fish in tank 15 ppt with survival rate is 75% and the lowest is at 32 ppt with 0% survival rate. This result was same with the growth rate and diameter of flesh. The relative growth rate was for 0 ppt and in 15 ppt shows the highest with . Both treatments show the almost same flesh diameter but treatment with 15 ppt shows the highest diameter 1.8 cm compared to 0 ppt is 1.7 cm. This shows that 15 ppt is best growth factor in this experiment. The experiment were conducted with the same dissolved oxygen, pH of the water, volume and also the temperature because any difference of this will cause the mortality and also the growth rate of the fish been effected. Obstacles or obstacles during or during the study can also be minimized by using the right steps.