Formulation and evaluation of antidiabetic bio-cream incorporated with aqueous extract albizia myriophylla benth (A. myriophylla)

The use of plants for medicinal purposes and the development of natural products is widespread, but ensuring the quality of these natural products remains a challenge. This research focuses on the extract of Albizia myriophylla Benth, which is traditionally used by the community in Pasir Mas, Kelantan, Malaysia, which is believed to be effective in preventing diabetes or lowering blood or body sugar levels among diabetic patients. This study mainly aimed to quantify the bioactive compounds in A. myriophylla and investigate its glucose-related properties while promoting skin benefits. In addition, it studied topical cream formulations combining A. myriophylla extract and natural ingredients, evaluating their quality through various parameters including organoleptic and physicochemical characteristics, antibacterial activity, microbial count, stability, and sensory evaluation, as well as skin irritation tests. The results showed that the formulated cream had good physical properties with a pleasant smell and exhibited antibacterial activity against E. coli and S. aureus, without the presence of colonies observed. A month-long stability test revealed that the cream remained stable under cold storage and room temperature, with no significant changes in odor, texture, or pH. User tests showed a high preference for the cream among respondents, with no skin irritation reported. Further research is warranted to evaluate the effectiveness of the cream in its antihyperglycemic and wound healing activities, potentially contributing to future developments in diabetes prevention and skin protection