The study aims to extract the mangosteen peel from Garcinia Mangostana L., using different solvent which is hexane, ethyl acetate, methanol, and distilled water. The extraction of this was done by Soxhlation method which is to determine the best solvent for extracting antioxidants from mangosteen peel. The analyse the antioxidant activity of mangosteen peel crude was determine by Gas Chromatography-Mass Spectrometry (GC/MS) Analysis, Fourier Transform Infrared (FTIR) Method Analysis, and antioxidant activity of mangosteen peel. The results were shows that crude extract of Garcinia Mangsostana L. Extraction yield the highest yield percentage was stated at 4.45% from ethyl acetate followed by methanol at 4.15% and 1.90% from hexane in using 40 grams of the powdered mangostana peel extract. While, in using 10 grams of the powdered the yield was 7.60% by using distilled water. During the antioxidant test, the present of IC50 for hexane which is at 25mg/ml concentration, followed by other solvent which is ethyl acetate (12.5 mg/ml), methanol (12.5 mg/ml), and distilled water (200 mg/ml). Ethyl acetate solvent was more effective because it’s have high antioxidants activity. This due to the solvents was a moderately polar solvents. Then, by using the mangosteen peel powder, it can be producing a skin care product which is scrub. Scrub can refer to a skin care product that can be used to exfoliate and cleanse the skin.