This study is to synthesis the green synthesis of silver nanoparticles (AgNPs) using Chromolaena odorota leaf extract by using three different solvent which is methanol, ethyl acetate and hexane as a reducing and stabilizing agent. The extraction is done using Soxhlet method. This eco-friendly approach offers cost-effectiveness and avoids harmful chemicals compared to conventional methods. Characterization techniques confirmed the formation of AgNPs, with visual observation suggesting successful synthesis within 24 hours. UV-Vis spectroscopy provided further evidence based on surface plasmon resonance, while FTIR analysis identified functional groups potentially involved in bioreduction and stabilization. The electron that rich oxygen atom in the C=O double bond can donate an electron to a silver ion. The FTIR spectra of leaf extract of C. odorota and the synthesized AgNPs were compared. However, the optimization of the synthesis process, using different solvent potentially enhance the inhibitory activity of AgNPs. Furthermore, stereoscopic microscope has been used to observe the C. odorota leaf cell. This research paves the way for further exploration of green-synthesized AgNPs from C. odorota leaves. Understanding their formation, characteristics, and potential for optimization can pave the way for their application in various fields, and nanomaterial development.