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Distribution pattern of ABO and RH blood groups and their allelic frequencies among different ethnic groups in Malaysia


Citation

Md. Ruhul Amin and Dwi Susanto and Laila Naher (2015) Distribution pattern of ABO and RH blood groups and their allelic frequencies among different ethnic groups in Malaysia. Asian Journal of Medical Sciences, 6 (4). pp. 25-29. ISSN 2091-0576

Abstract

The experiment involved 4 different racial populations such as Malay (M), Chinese (C), Indian Tamil (I) and confounded population termed as Others (O) from 13 states and 1 federal territory in Malaysia. Methods: A total of 1101 students in Universiti Malaysia Kelantan were surveyed for ABO blood type and Rh factor. Results: Phenotypic frequencies were 0.24, 0.27, 0.09 and 0.40 in M; 0.26, 0.21, 0.06 and 0.38 in C; 0.27, 0.31, 0.09 and 0.33 in I and 0.11, 0.29, 0.09 and 0.51 in O for A, B, AB and O blood group, respectively. Rh+ve cases were found to be abundant and distributed as 0.92, 0.94, 0.89 and 0.79 among M, C, I and O race, respectively. Allele frequencies of IA, IB and I were estimated at 0.17, 0.20 and 0.63 in M; 0.19, 0.16 and 0.65 in C; 0.20, 0.23 and 0.57 in O, respectively. Insignificant χ2(0.05, 2 = 5.991) interprets that ABO allele frequencies exist in Hardy-Weinberg equilibrium in all races. However, high magnitude of χ2 in M (5.463) signifies continued admixture in the M genetic population or the population is less stable than C and I. C and I are in more stabilized condition in this regard that might be because of closed breeding within them.Conclusion: Results of this study might be useful to blood transfusion services in Malaysia apart from human population geneticists.

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Additional Metadata

Item Type: Non-Indexed Article
Collection Type: Institution
Date: 2015
Journal or Publication Title: Asian Journal of Medical Sciences
ISSN: 2091-0576
Uncontrolled Keywords: ABO Blood group, Race, Rh factor, Hardy-Weinberg Law, Malaysia
Faculty/Centre/Office: Faculty of Agro - Based Industry
URI: http://discol.umk.edu.my/id/eprint/8129
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