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Pathological changes induced by chronic exposure to lead acetate and treatment with calcium disodium edetate in broilers


Imad Ibrahim Ali Al-Sultan and O. E.Ibrahim and T.A. Makkawi (2011) Pathological changes induced by chronic exposure to lead acetate and treatment with calcium disodium edetate in broilers. Journal of Advanced Biomedical & Pathobiology, 1. pp. 26-31. ISSN 2231-9123


Lead is one of the major contributing agents to ever-increasing environmental pollution (Narayana and Al-Bader,2011).Lead (Pb) is a neurotoxic heavy metal and children in the development stage are particularly susceptible to toxic effects of lead exposure(Ponnusamy et al.,2008).The current study evaluate the impact of chronic lead acetate(LA) toxicity on tissue reactions and after treatment with 5% calcium disodium edetate (CDE) as responses to accumulative and destructive cellular effect in pathological terms using broiler chickens as an experimental model for human disease. Thirty, 7 week-old broiler chicken of Ebba2000 breed were used in the experiment. The toxic dose for chicken was 2 gm/kg bw (Al-Sultan et al., 2011). Broilers were divided into 3 groups, of 10 birds each. The 3rd group was not treated and used as a control. To induce chronic toxicity with the lead compounds, both groups 1 & 2 were given the sub toxic dose in an amount of 1 gm/kg bw respectively. Group two were treated with 5% CDE. Pathological changes in chickens that developed chronic toxicity and treated were structurally highly observed. However, there was a positive correlation between the concentration of lead in the blood and the intensity of damage to the tissues and organs before and after treatment.

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Additional Metadata

Item Type: Non-Indexed Article
Collection Type: Institution
Date: 2011
Journal or Publication Title: Journal of Advanced Biomedical & Pathobiology
ISSN: 2231-9123
Uncontrolled Keywords: Lead acetate - Chronic toxicity - Pathology - Chicken - Calcium disodium edetate
Subject Heading: Chronic toxicity testing
Subject Heading: Broilers (chickens)
Subject Heading: Pathology
Faculty/Centre/Office: Faculty of Veterinary Medicine
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