A study of PCL10 at different oil in water volume ratio using polyvinyl alcohol, sugar ester as surfactant

The preparation of PCL colloidosome at different oil in water ratio by using polyvinyl alcohol (PVA) and S1670 (based of sugar ester) as surfactants. The preparation of PCL colloidosome were carried out by using two steps of solvent evaporation method. The study were carried out in three different parameters. The first parameter is, different volume of oil phase and second is using, two different types of surfactant (PVA and S1670) were used while keep constant the value for their concentration at (1.2 wt%). The third parameters utilized for the same type of stablizer, S1670 but their concentration were diversified such as S1670 (1.2 wt%) and S1670 (0.1 wt%). Effects for all of three parameters such as particle stability, average size of particle, yield of particle and surface tension were determined. The higher volume of oil to water phase ratio, the larger size of particle formed. By using PVA as stablizer in colloidosome preparation, the size of colloidosomes formed are larger than used of S1670. When the colloidosomes from all of the three systems were compared together, their size are in various of microns and due to that, it resulted to some features such as rate of active agent release and degradation rate of colloidosomes which are related to the specific target application, either for short or long term recovery application. As this study aims toward an injectable scaffold as a microparticle carrier, the selection of colloidosome are depends on their target application for example, large sized of colloidosomes are suitable to apply in long term recovery application and contrast to the small particles sized.