This study is aim to screen the presence of antimicrobial activity of Babylonia areolata against specific pathogen which is Aeromonas hydrophila. This study was carried out to detennine the effectiveness of B. areolata against A. hydrophila which tends to be a serious threat to the aquaculture and human health as well. Two different extraction solvents were used; ethanol and methanol to extract the homogeneous body of B. arealata and the antimicrobial activity was canied out by using agar well diffusion method. The bacterial pathogen was showed maximum susceptibility inhibition zone, ll.67±l.53 mm against ethanol extract of B. areolata compared to inhibition zone of methanol extract, 8.67±1.15 mm. The finding showed that the gastropod species are rich in antimicrobial properties when react against isolated microbes. Further studies need to be conducted to investigate the full structural component of antimicrobial compound derived from marine molluscs. The result obtained can be used as a guideline for further
research in this field at the future.