The blue pea flower. dragon fruit and pandan leaves are native plants of Malaysia which are widely used in everyday lives as food colourant. The objective of this research is to study the solubility of formulated lipstick using natural and synthetic colorants in different organic solvents. In this research the method of extraction and analysis are used in which data analysis is using SPSS 20 software. The heat and colour stability tests are done at temperature 30, 37, 40, 50, 60, 70 and 80˚C with light and dark conditions. It was found that the heat stability test showed temperature did have effect on colour intensity of the plants in which the colours faded while the colour stability test indicated colour degradation as approaching day 14. Formulated lipsticks (natural and synthetic) have different solubility in the organic solvents tested. Thus, research suggests that formulated lipsticks (natural) were more soluble in all type of organic solvents.