Heavy metal has gravely increased worldwide attention and under certain environmental condition. The aquatic organisms such as freshwater prawn may concentrate large amount of metal from water in their tissue. Cadmium is a heavy metal that considerably toxicity with destructive impact on most organ systems. Cd was former used in the many industrial activities for a long period of time. In this review, the post larvae M. rosenbergii, were exposed to different concentration of Cd in soft water. The concentrations of Cd that has been used were 20 ppb, 40 ppb, 60 ppb, 80 ppb and 100 ppb and control without Cd concentration. The post larvae were used because they consistently more sensitive. A 4 days exposure period 24, 48, 72 and 96 hours appears to be appropriate for determining post larval sensitivity to Cd. The post larvae(PL) exposed at 28 °C, salinity is 28, pH 7.76 and the dissolved oxygen is 4.8 mg/L. The concentrations were triplicate and 30 post larvae per tank were used. The objective of this study was to determine the acute level of cadmium on the freshwater prawn, M. rosenbergii, PL. After 96 hours exposed to the different concentration of Cd, the result showed higher significant effect between the between the studied concentrations of Cd. Result also demonstrated the highly toxic even for short term exposure to 20-100 ppb of Cd in PL. In conclusion, the 100 ppb was the maximum concentration that showed the 100% mortality on post larvae.