Synthesis of silver nanoparticles brings many advantage in various fields of nanotehchnology. Diabetes mellitus is a chronic disorder which occurs due to insulin deficiency. The disease is of diabetes mellitus is increasing around the world. Green synthesis of nanoparticles using plant extracts have been popular because of its none toxicity of side effects. Piper betel is one of the plants with many medicinal properties. It propagated widely on India, China and southeast-asiatic countries. There are many studies been made on this plant by researchers. However, few study have been made on synthesis of silver nanoparticles from the species. This project is proposed to synthesis silver nanoparticles using green synthesis method and test their antidiabetic potential. Silver nanoparticles will be characterised using UV visible spectroscopy, SEM, FTIR and XRD. At the end of this project, silver nanoparticles from Piper betel will be synthesised and its antidiabetic potential is tested using alpha amylase enzyme. The results from this project will give ideas on future studies to develop drugs based on medicinal plant in nanotechnology.