This study aims to investigate the relationships between motivation, mental health, learning style, and academic performance among students of commerce program at Universiti Malaysia Kelantan. This study is driven by the need to understand the various elements that influence students' performance in higher education, particularly in the context of a competitive labor market and an information-driven economy. This study underlines the research framework based on theory of self-determination in education which consist motivation, mental health and learning style towards academic achievement. A total of 450 questionnaire were e-mail to the selected respondent using simple random sampling. The usable 300 questionnaires, which had a valid response rate of 67 percent, were analyzed using SPSS for descriptive analysis, correlation and regression analysis. The finding of this study shows that motivation, mental health and learning style have positive and significant relationship with academic performance of the students. From the regression analysis found that learning style have not influence academic performance of the study, but motivation and mental health have shown significant influenced on academic achievement of the student. Overall, this study provides a better insight and understanding of student academic performance benefiting to the university, Ministry of Higher Education, lecturer and policy maker.