Estrus synchronization, which is a reproductive process manipulation, offers a number of advantages. Several estrus synchronization protocols have been developed, each of which employs a combination of drugs and products to modify hormonal changes in the female estrus cycle. Since different reproductive hormones are used in estrus synchronization, having a simple understanding of them will help farmers figure out the protocol would function best for their herd. Controlled Internal Drug Release (CIDR) is a popular method of obtaining estrus in female cattle that is also used commercially. This method, on the other hand, is costly and has many drawbacks especially to small-scale farmers. Therefore, an alternative method of herbal treatment, which is cheaper and easy to obtain will be use as a replacement of CIDR device. The purposes of this study are (1) to compare secondary estrus signs, estrus onset and duration of estrus between CIDR and herbs treatment in cattle and (2) to determine the efficiency of CIDR and herbs on pregnancy rate. 8 cows were divided into two groups in this study, (A) Herbs group (n = 5) and (B) CIDR group (n=3). Estrus sign were observed for 45 minutes at 0700, 0900, 1100, 1300, 1500, 1700, 1900, and 2100. The observation was carried out after three days of continuous feeding of modified herbs (A) and CIDR withdrawal (n=7days)(B). The cattle were mated naturally followed by pregnancy diagnosis with rectal palpation, and urine test (PregnaDrop). Restlessness and sniffs the other vulva in Group A (Herbs) showed significantly higher (P<0.05) compared to Group B(CIDR). All primary estrus signs of Group A (Herbs) in the evening showed significantly higher than Group B (CIDR). Secondary signs which vulva swelling and reddening showed 100% (n=8) for both treatments. The outcome of this study showed that Herbs can be a replacement of CIDR in estrus synchronization.