The development of Information Technology (IT) brings the internet a positive impact on daily life, including the way people sell and buy via online or known as online business. So, this study is to identify the factor that influence the successful online business among students in City Campus Universiti Malaysia Kelantan. A research framework comprising different variables like digital marketing skills and knowledge management which influence successful online business. 364 respondents took part in this research, which was done using quantitative research methodology. The Statistical Package for the Social Sciences (SPSS) was used to analyze collected data. As a result, numerous methodologies, including descriptive, reliability, and normality analysis, were used to analyze the data obtained from the online questionnaire survey. The results imply that the independent variables and dependent variables have a significant relationship.