Graphene oxide antifungal activities against aspergillus versicolor

An abstract of the research paper presented to the Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, in partial requirement on the course DVT 55204 – Research Project. Aspergillosis is a common fungal disease in animals and humans. The existing treatment of conventional antifungal may have disadvantages as it can cause liver damage, severe allergic and increasing resistance towards the compound makes it partially effective. Therefore, it is important to find an alternative therapy for the problem. Recently, the application of carbonbased nanoparticles such as graphene oxide (GO) has received attention for biomedical application. GO has been tested for its antibacterial properties and showed some promising outcomes. However, it is unknown if the GO can also demonstrate antifungal properties. In this research, we aimed to determine GO fungicidal activity against Aspergillus versicolor and the
toxicity in mammalian cells. Based on the results, GO have fungicidal activity against Aspergillus versicolor as we can observe inhibition zone of GO on the agar plate streaked with Aspergillus versicolor. Also, GO is less toxic towards mammalian cells as it can induce cell proliferation of Mardin-Darby Canine Kidney (MDCK) cells.
Keywords: Graphene Oxide, Mardin-Darby Kidney cells, fungicidal activity, antifungal, toxicity cell growth, Aspergillosis