E-learning is widely used as an educational approach around the globe, specifically during the COVID-19 pandemic. Rapid technology advancements and widespread access to the Internet enabled the growth of this approach. This research aimed to determine the significant impacts of e-learning on the academic performance of university students in Malaysia during the COVID-19 pandemic. Thus, this study empirically measures the extent of a lack of motivation, mental health, and procrastination behaviour on the academic performance of university students. This study was structured through a self-administered survey with university students in Malaysia who were identified and chosen for data collection. With 384 respondents, the data were analysed by descriptive, frequency, and inferential analysis using SPSS. These findings show that e-learning has the greatest impact on the academic performance of university students in Malaysia during the COVID-19 pandemic.