A systematic review on curcumin as an anti cancer treatment in canine prostate carcinoma

Canine prostate carcinoma is a malignant cancer that is able to rapidly proliferate and metastasize to other body systems. It has low prevalence; about 1%. It is mostly diagnosed in median age dogs especially in dogs aged more than 10 years age. Canine prostate carcinoma has poor prognosis with limited treatment options and poor outcomes of these treatments. Curcumin (diferuloylmethane) is a derivative of Curcuma longa, from family Zingiberaceae. It is contains polyphenolic compound, curcuminoids that is a potent tumor suppressor due to its property of stimulating apoptosis by triggering cell cycle arrest and suppress oncogenic pathway. The collective information on the use of curcumin for canine prostate carcinoma treatment is disjoined and not readily accessible for clinical and academic reference. This is a systemic review to summarise the researches done with curcumin as a potential anti-cancer treatment for canine prostate carcinoma. Thus, a total of 2,154 publications were collected from Science Direct and PubMed using 12 search phrases. 19 published articles have met the set research criteria. Even though, there aren’t any published articles on curcumin as anti-cancer treatment for canine carcinoma, it shows great potential to be used in treatment for canine prostate carcinoma. Several researches are already been conducted in human prostate cancer using curcumin as anti-cancer treatment that shows promising outcome. Study and research on curcumin as canine prostate carcinoma treatment should be at prompt given its great potential to work alone and work synergistically with practicing anti-cancer treatments.
Key words: Curcumin, Prostate cancer, Canine, Therapy