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Characterization of sensitivity human pathogens against selected commercial antibiotics and plant extract


Norasmaliza Abd Ghafar (2019) Characterization of sensitivity human pathogens against selected commercial antibiotics and plant extract. Masters thesis, Universiti Malaysia Kelantan. (Submitted)


Antibiotics give the most important source for the rehabilitation of microbial infection. Thus, in the presence of the global spread of resistant clinical isolates, the need to find new antimicrobial agents is one of the greatest importance challenge The present study was designed to characterize the human most pathogenic bacteria which been isolated from human clinical samples, evaluate the antimicrobial of 19 common commercial antibiotics and the susceptibility activities of 23 plant extracts against the isolated pathogen. The prospective observational study revealed the presence of 11 isolations of most human pathogenic microorganisms being isolated from the hospital institution. The isolations show a different pattern of antibiotic susceptibility against 19 antibiotics. Twenty-three plant ethanol extract were studied for antimicrobial activity by using well diffusion assay. The isolated microorganism shows the largest zone of inhibition was obtained by the plant extract of Tyhonium flagelliforms. The antimicrobial activities of extracts were then compared with 11 standard antibiotics like amoxicillin, amikacin, ciprofloxacin and gentamicin. It is concluded that the data revealed the Gram-Positive microorganisms were further sensitive than Gram-Negative against the plant extracts studied. The ethanol extract of other plants which has been tested might be a possible basis to gain novel and operative plants treatments to treat infections from the public as well as hospital surroundings. Nevertheless, it is essential to decide the toxicity of active elements, their side effects and pharmacokinetic assets.

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Additional Metadata

Item Type: UMK Etheses
Collection Type: Thesis
Date: 2019
Subject Heading: Plant extract
Subject Heading: Antibiotics
Subject Heading: Human pathogens
Subject Heading: Plant-pathogen relationships|
Number of Pages: 91
Call Number: SB732.7 .N67 2019 tes
Supervisor: Prof. Madya Dr. Lee Seong Wei
Programme: Master of Science
Institution: Universiti Malaysia Kelantan
Subjects: S Agriculture > SB Plant culture
Faculty/Centre/Office: Faculty of Agro - Based Industry
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